Stephanie van Hoppe

161 The impact of OATPs on disposition and toxicity of antitumor drugs; insights from KO and humanized mice H. Glaeser, D.G. Bailey, G.K. Dresser, J.C. Gregor, U.I. Schwarz, J.S. McGrath, E. Jolicoeur, W. Lee, B.F. Leake, R.G. Tirona and R.B. Kim, Intestinal drug transporter expression and the impact of grapefruit juice in humans, Clin Pharmacol Ther 81 (2007), pp. 362-370. J. Gligorov and J.P. Lotz, Preclinical pharmacology of the taxanes: implications of the differences, Oncologist 9 Suppl 2 (2004), pp. 3-8. I.Y. Gong and R.B. Kim, Impact of genetic variation in OATP transporters to drug disposition and response, Drug Metab Pharmacokinet 28 (2013), pp. 4-18. L. Gong, N. Aranibar,Y.H. Han,Y. Zhang, L. Lecureux,V. Bhaskaran, P. Khandelwal, C.D. Klaassen and L.D. Lehman- McKeeman, Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles, Toxicol Sci 122 (2011), pp. 587-597. M.A. Grenier and S.E. Lipshultz, Epidemiology of anthracycline cardiotoxicity in children and adults, Semin Oncol 25 (1998), pp. 72-85. C. Gui, Y. Miao, L. Thompson, B. Wahlgren, M. Mock, B. Stieger and B. Hagenbuch, Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3, Eur J Pharmacol 584 (2008), pp. 57-65. J.Y. Han, H.S. Lim, E.S. Shin, Y.K. Yoo, Y.H. Park, J.E. Lee, H.T. Kim and J.S. Lee, Influence of the organic anion- transporting polypeptide 1B1 (OATP1B1) polymorphisms on irinotecan-pharmacokinetics and clinical outcome of patients with advanced non-small cell lung cancer, Lung Cancer 59 (2008), pp. 69-75. G.R. Harlow and J.R. Halpert, Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics, Proc Natl Acad Sci U S A 95 (1998), pp. 6636-6641. J.W. Higgins, J.Q. Bao, A.B. Ke, J.R. Manro, J.K. Fallon, P.C. Smith andM.J. Zamek-Gliszczynski, Utility of Oatp1a/1b- knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein, Drug Metab Dispos 42 (2014), pp. 182-192. R.A. Hilger, H. Richly, M. Grubert, S. Kredtke, D. Thyssen, W. Eberhardt, J. Hense, M. Schuler and M.E. Scheulen, Pharmacokinetics of sorafenib in patients with renal impairment undergoing hemodialysis, Int J Clin Pharmacol Ther 47 (2009), pp. 61-64. R.S. Holmes, M.W. Wright, S.J. Laulederkind, L.A. Cox, M. Hosokawa, T. Imai, S. Ishibashi, R. Lehner, M. Miyazaki, E.J. Perkins, P.M. Potter, M.R. Redinbo, J. Robert, T. Satoh, T. Yamashita, B. Yan, T. Yokoi, R. Zechner and L.J. Maltais, Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins, Mamm Genome 21 (2010), pp. 427-441. S. Hu, R.M. Franke, K.K. Filipski, C. Hu, S.J. Orwick, E.A. de Bruijn, H. Burger, S.D. Baker and A. Sparreboom, Interaction of imatinib with human organic ion carriers, Clin Cancer Res 14 (2008), pp. 3141-3148. S. Hu, R.H. Mathijssen, P. de Bruijn, S.D. Baker and A. Sparreboom, Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations, Br J Cancer 110 (2014), pp. 894-898. M.T. Huisman, J.W. Smit, K.M. Crommentuyn, N. Zelcer, H.R. Wiltshire, J.H. Beijnen and A.H. Schinkel, Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs, AIDS 16 (2002), pp. 2295-2301. F. Innocenti, D.L. Kroetz, E. Schuetz, M.E. Dolan, J. Ramirez, M. Relling, P. Chen, S. Das, G.L. Rosner and M.J. Ratain, Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics, J Clin Oncol 27 (2009), pp. 2604-2614. D. Iusuf, J.J. Hendrikx, A. van Esch, E. van de Steeg, E. Wagenaar, H. Rosing, J.H. Beijnen and A.H. Schinkel, Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel, Int J Cancer 136 (2015), pp. 225-233. D. Iusuf, M. Ludwig, A. Elbatsh, A. van Esch, E. van de Steeg, E. Wagenaar, M. van der Valk, F. Lin, O. van Tellingen and A.H. Schinkel, OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice, Mol Cancer Ther 13 (2014), pp. 492-503. D. Iusuf, R.W. Sparidans, A. van Esch, M. Hobbs, K.E. Kenworthy, E. van de Steeg, E. Wagenaar, J.H. Beijnen and A.H. Schinkel, Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice, Mol Pharm 9 (2012a), pp. 2497-2504. D. Iusuf, E. van de Steeg and A.H. Schinkel, Functions of OATP1A and 1B transporters in vivo: insights from mouse models, Trends Pharmacol Sci 33 (2012b), pp. 100-108.