Stephanie van Hoppe

185 Curriculum Vitae C UR R I C U LUM V I TA E Stéphanie Sigrid van Hoppe was born on April 7th 1986 in Bonaire (the Netherlands Antilles). After graduating high school at Radulphus College in Curaçao (the Netherlands Antilles), she chose to study Molecular Life Sciences at the University of Maastricht (the Netherlands). She received her B.Sc. degree in 2010. During the last year of her bachelors she enrolled in the Topmaster program Oncology at the Free University (VU) in Amsterdam (the Netherlands) where she completed two internships. During her first internship in the laboratory of Prof. Dr. Tom Würdinger at the Cancer Center of Amsterdam (CCA), she researched the development of a multiplex bioluminescent reporter system in vitro and in vivo under the supervision of Dr. Sjoerd van Rijn. She completed her second internship in the lab of Prof. Dr. Bakhos Tannous at Massachusetts General Hospital (MGS) & Harvard Medical School (HMS) (the United States of America), where she researched novel anti-cancer treatments in vitro and in vivo under the supervision of Dr. Christian E. Badr, which led to a second author publication. End of 2013 Stéphanie received her M.Sc. degree and subsequently in 2014, she started her PhD program in the lab of Dr. Alfred H. Schinkel at the Netherlands Cancer Institute (the Netherlands). During her PhD, she studied the pharmacological functions of ABC efflux and OATP uptake transporters in the disposition of (anti-cancer) drugs in vitro and in vivo . These projects were conducted in collaboration with the research laboratory of Prof. Dr. Jos H. Beijnen at the Netherlands Cancer institute/ Slotervaart Hospital and Utrecht University (the Netherlands). The results obtained during her PhD are described in this thesis.