Stephanie van Hoppe

189 Acknowledgements A big thank you to all the people I collaborated with, or who’ve helped me out in my research: Piet Borst , Gert-Jan Rood , Levi Buil , Sjoerd Klarenbeek , Sovann Kaing , Krijn Dijkstra , Dirk deWaart , DesireeVerwoerd , Dick Pluim, the animal caretakers at G5 and T1 andT2 , Leo Ennen, Maaike van der Meulen , AnneMarie Rhebergen, Roel Sneepers , Filip Mulkens and the intervention unit . Thank you Piet for the fruitful discussions and your advice concerning my projects. I highly admire your knowledge and critique on all the various scientific projects. Gert-Jan , thank you for your collaboration on the ibrutinib and the osimertinib projects. I’ve enjoyed working with you and discussion our results together. Also a big thank you for your willingness to give some guidance to my student while he was measuring samples there in Utrecht. I look forward to seeing your thesis! Levi , thank you for helping me out during my busy in vivo experiments! I enjoyed working with you as it was a perfect balance of hard work and having fun! I admire that you always remained very calm and collected no matter what happened. Masha masha danki! Sjoerd , thank you for all the nice discussions we’ve had about the OATP project. Unfortunately this did not end up in this thesis, but I wanted to acknowledge your efforts either way. I am grateful that you were so approachable for any questions I had. Sovann , thank you for teaching me all about culturing organoids and for being so helpful! Also a thank you to Krijn for handing me all those organoids for staining. This project did not make it here, but I remain very thankful for efforts! It was also nice sharing the office with you on H5 for a short period in the ‘old’H5, as well as being in the party committee together. Rudy , thank you for measuring my bile acid samples, even though these did not make it to this thesis, your efforts won’t go unnoticed of course! Desiree , thank you for your help in the RNC for both the in vitro and in vivo experiments along with the nice conversations we’ve had! The results of these studies are not in this thesis, but I hope these will be published in the near future. Dick , thank you for helping me measure with the HPLC in the RNC so I could continue setting up my experiment. And to all the animal caretakers in the old and new building, thank you all so much for your help with the mice and the nice atmosphere. A special thanks goes to Desiree de Wilt for the nice conversations we’ve had and for being so helpful. And thank you Maaike for all your help concerning the DECs and the WPs that needed to be adapted. You were always ready to help out. And to Roel, Filip and Anne Marie , thank you for helping me out with the in vivo techniques and always being very friendly and helpful whenever I had any questions. Also thank you to Niels deWit and Natalie Proost for all your help during my radioactive in vivo experiment at T1. To all the former and current members of the Schinkel lab: Selvi Durmus , Anita Kort, Els Wagenaar, Seng Chuan Tang, Yaogeng Wang , Jing Wang, Chanpei Gan, Xiaozhe Qi, Cristina Mesquita Lebre, Wenlong Li and Margarida Martins, thank you all for contributing to my research and coloring my life one way or another. Selvi , you’ve left