Stephanie van Hoppe

38 Chapter 2 Supplementary Figure 1 - Plasma concentration-time curves in female WT (black circles) and Abcg2;Abcb1a/1b -/- (red squares) over 8 hours after oral administration of 10 mg/kg afatinib. Data are given as mean ± SD. Supplementary Figure 2 - Brain and liver concentration (A, D), tissue-to-plasma ratio (B, E) and relative accumulation (C, F) of afatinib in female WT and Abcg2;Abcb1a/1b -/- mice 8 h after oral administration of 10 mg/kg afatinib. Data are given as mean ± SD. S U P P L EME N TA L MAT E R I A L