Stephanie van Hoppe

65 Brain accumulation of osimertinib and its active metabolite is restricted by ABCB1 & ABCG2 Supplemental Figure 2 - Plasma concentration-time curves of osimertinib in male wild-type (WT) (black circles), Abcb1a/1b;Abcg2 -/- (light-blue squares) and Cyp3a -/- (maroon triangles) mice, over 24 h after oral administration of 10 mg/kg osimertinib. Data are given as mean ± SD. N = 4-5 mice per group. Supplemental Figure 2. Plasma concentration-time curve of osimertinib in ale wild-type (WT) (black circles), Abcb1a/1b;Abcg2 -/- (light-blue squares) and Cyp3a -/- (maroon tria gles) mice, over 24 h after oral administration of 10 mg/kg osimertinib. Data are given as mean ± SD. N = 4-5 mice per group. 0 2 4 6 8 10 12 14 16 18 20 22 24 0 200 400 600 time (h) Osimertinib plasma concentration (ng/ml) WT Abcb1a/1b;Abcg2 -/- Cyp3a -/-