Stephanie van Hoppe

4 P-glycoprotein (MDR1/ABCB1) restricts brain penetration of the Bruton’s tyrosine kinase inhibitor ibrutinib while Cytochrome P450-3A (CYP3A) limits its oral bioavailability Stéphanie van Hoppe 1 , Johannes J.M. Rood 2 , Levi Buil 1 , Els Wagenaar 1 , Rolf W. Sparidans 2 , Jos H. Beijnen 1, 2 , Alfred H. Schinkel 1 1 Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam 2 Section of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht Mol Pharm . 2018 Nov 5;15(11):5124-5134.