Stephanie van Hoppe

93 ABCB1 restricts brain penetration of the BTK inhibitor ibrutinib while CYP3A limits its oral bioavailability Supplemental Figure 3 - Ibrutinib-DiOH (DiOH) to ibrutinib concentration ratios in female WT (black circles) and Abcb1a/1b;Abcg2 -/- (green squares) mice over 3 h after oral administration of 10 mg/ kg ibrutinib. Data are given as mean ± SD. n = 5−6 mice per group. Supplemental Figure 4 - Ibrutinib-DiOH (DiOH) to ibrutinib concentration ratios in female WT (black circles) and Abcb1a/1b;Abcg2 -/- (green squares) mice over 1 h after oral administration of 10 mg/ kg ibrutinib. Data are given as mean ± SD. n = 5−6 mice per group.