Stephanie van Hoppe

96 Chapter 4 Supplemental Figure 8 - Plasma concentration−time curves of ibrutinib ( A ) and ibrutinib-DiOH (DiOH) ( B ) and DiOH to ibrutinib concentration ratios ( C ) in plasma of female WT (black circles) and Cyp3a -/- (blue squares) mice over 1 hour after oral administration of 10 mg/kg ibrutinib. Data are given as mean ± SD. n = 5−6 mice per group.