Stephanie van Hoppe

5 Brain accumulation of ponatinib and its active metabolite N-desmethyl ponatinib is limited by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) Stéphanie van Hoppe a# , Anita Kort a,c# , Rolf W. Sparidans b , Els Wagenaar a , Jos H. Beijnen b,c,d and Alfred H. Schinkel a* a Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam b Division of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, c Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/ Slotervaart Hospital, Amsterdam d Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam Mol Pharm. 2017 Oct 2;14(10):3258-3268.