Els van Meijel

The research described in this thesis was financially supported by the Netherlands Organization for Health Research and Development (ZonMw). The printing of this thesis was financially supported by De Bascule. Cover design Anne van Meijel Layout Anouk Westerdijk | persoonlijkproefschrift.nl Printed by Ridderprint | www.ridderprint.nl ISBN 978-94-6375-550-4 © 2019 Els PM van Meijel, Arnhem, the Netherlands No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage or retrieval system, without permission in writing from the author.