102 CHAPTER 5 (mean minus two-times the standard deviation of the unmutated BCR distribution at baseline) (figure 2B, grey and black arrow). Using these definitions, we observed that out of the 23 patients, 14 (61%) reached their post-depletion endpoint at month 1, 19 (83%) at month 3, and 23 (100%) at month 6 after treatment (figure 2C, grey line). Regarding B cell repopulation, cumulatively 2 (9%) patients reached their post-repopulation endpoint at month 3, 9 (39%) at month 6, and 14 (61%) at month 12 after treatment (figure 2C, black line). In the remaining 9 (39%) patients no post-repopulation timepoint could be defined within the follow-up period of 1 year. In conclusion, using this novel approach our data confirm that B-cell depletion is achieved within one month of treatment in the majority of the patients, and show that B cell repopulation takes more than 12 months in one third of the treated patients.
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