64 CHAPTER 4 articles published in English between 2010 and 2021. Articles were independently screened by two researchers (GF, AM) based on title and abstract, followed by full text. Selected articles were divided into three categories depending on their subject: background information, RCTs, and patient perspectives. Additional articles, conferences abstracts and reports were manually included after the search by the authors. The search, screening, and articles inclusion were done accordingly to the Cochrane Collaboration guidelines for a systematic literature review on interventions [39]. Summary of results A total of 1821 articles were screened, following the before mentioned criteria. Of those, 18 duplicates and 122 papers in non-English were removed. Thus, a total of 1681 articles were eligible for inclusion. At the end of the first screening step, 22 articles were included and 8 additional relevant reports were added. Hand-selected reports included published articles and abstract presented at conferences. After the second screening phase, 8 articles were excluded, for a final count of 22 articles. Figure 1 reports a summary of the search and inclusion process.
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