73 Prevention of rheumatoid arthritis Table 1 | Summary table of preventive interventional trials in individuals at risk of developing rheumatoid arthritis (continued) Trial name Inclusion criteria Number of patients (treatment vs placebo) Intervention Time of follow-up Primary outcome Secondary outcome Results Reference TREAT EARLIER - CSA less than 1 year - Subclinical i n fl ammation of hand/ feet joints by MRI scan of hands or forefeet 236 patients (119 treatment vs 117 placebo) 120 mg methylprednisolon at baseline + increasing dose of methotrexate up to 25 mg/week - 52 weeks - 2 years - Clinical arthritis for ≥ 2 weeks - RA progression as per ACR/ EULAR 2010 criteria - DMARD-free status - Productivity and impairment scale - Symptoms (pain, fatigue, morning stiffness) - No difference in RA onset - Delayed RA onset in subgroup of patients with high risk - Decreased joint inflammation by MRI in treatment group at 1 year -Decreased disease-related symptoms, physical impairment and loss of productivity in treatment group at 1 year [53-55] The effectiveness in preventing the development of rheumatoid arthritis in patients with Undifferentiated inflammatory arthritis and to evaluate Safety and Tolerability. UA=Undifferentiated arthritis. RA=Rheumatoid arthritis. ACPA=Anti-Citrullinated Proteins Antibodies. ACR=American College of Rheumatology. MRI=Magnetic Resonance Imaging. RF=Rheumatoid Factor. DAS28=Disease Activity Score of 28 joints. CRP=C-reactive protein. APIPPRA=Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept. CSA=Clinical Suspected Arthralgia. EULAR= European Alliance of Associations for Rheumatology. DMARDs=Disease Modifying Anti-Rheumatic Drugs. ARIAA=Abatacept Reversing subclinical Inflammation as measured by MRI in ACPA positive Arthralgia. HLA= Human Leukocyte Antigen. SE=Shared Epitope. PRAIRI=Prevention of clinically manifest rheumatoid arthritis by B-cell directed therapy in the earliest phase of the disease. PROMPT=PRObable rheumatoid arthritis: Methotrexate versus Placebo Treatment. SAVE=Stop Arthritis Very Early. STAPRA=STAtins to Prevent Rheumatoid Arthritis. SJC44=Swollen Joint Count among 44 joints. TREAT EARLIER=TREAT Early Arthralgia to Reverse or Limit Impending Exacerbation to Rheumatoid arthritis. 4
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