74 CHAPTER 4 A B Figure 2 | Overview of preventive interventional trials In blue trials investigating glucocorticoids, in yellow conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs), in green biological (b)DMARDs, and in purple statins. HCQ=hydroxychloroquine. ADJUST=Abatacept study to Determine the effectiveness in preventing the development of rheumatoid arthritis in patients with Undifferentiated inflammatory arthritis and to evaluate Safety and Tolerability. APIPPRA=Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept. ARIAA=Abatacept Reversing subclinical Inflammation as measured by MRI in ACPA positive Arthralgia. PRAIRI=Prevention of clinically manifest rheumatoid arthritis by B-cell directed therapy in the earliest phase of the disease. PROMPT=PRObable rheumatoid arthritis: Methotrexate versus Placebo Treatment. SAVE=Stop Arthritis Very Early. STAPRA=STAtins to Prevent Rheumatoid Arthritis. TREAT EARLIER=TREAT Early Arthralgia to Reverse or Limit Impending Exacerbation to Rheumatoid arthritis. (A) Timeline of preventive interventional studies. (B) Overview of preventive interventional trials based on their target population.
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