Albertine Donker

The research presented in this thesis was performed at the Translational Metabolic Laboratory, part of the Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands and at the Department of Pediatrics, Máxima MC, Veldhoven, the Netherlands. Publication of this thesis was financially supported by the Radboud University Nijmegen, the Netherlands. ISBN: 978-94-6375-869-7 Thesis number: RIMLS 2020-23 Cover design and layout: © evelienjagtman.com Print: Ridderprint, www.ridderprint.nl About the cover: The cover painting represents a paraphrase of a quote by Isaac Newton (1643-1727): “In science we resemble children picking a few flowers from the garden of knowledge, while the wide sky of the unknown unfolds itself above us.” Copyright © 2020 Albertine Donker, Veldhoven, the Netherlands All rights reserved, no part of this thesis may be reproduced, stored in a retrieval system of transmitted in any form or by any means without prior permission of the author.