Albertine Donker

Chapter 7 236 Table 2. Reference ranges for serum hepcidin, ferritin/hepcidin ratio and TSAT/hepcidin ratio per age group and sex Males Hepcidin a (nmol/L) Age (years) n(%) Median p25-p75 Min-Max 0 - < 2 11 (7) 1.8 1.1-7.3 0.9-20.9 2 - < 6 29 (19) 2.0 1.0-3.3 0.1-7.0 6 - < 12 71 (45) 1.7 0.9-3.4 0.1-15.5 12 - < 18 46 (29) 0.7 0.3-1.8 0.0-9.3 Total 157 (100) 1.5 0.7-3.0 0.0-20.9 Hepcidin/ferritin (pmol/µg) Age (years) 0 - < 2 11 (7) 49.7 34.5-124.0 11.4-302.6 2 - < 6 28 ((18) 54.0 36.9-94.8 4.6-216.5 6 - < 12 71 (46) 43.7 23.8-82.6 2.9-249.6 12 - < 18 46 (29) 18.2 5.6-31.3 0.5-106.0 Total 156 (100) 35.0 18.8-67.4 0.5-302.6 TSAT/hepcidin (%/nmol/L) Age (years) 0 - < 2 11 (7) 11.4 2.5-13.8 0.2-22.4 2 - < 6 28 (18) 10.9 6.6-24.3 2.5-230.9 6 - < 12 71 (46) 14.0 7.4-25.9 0.5-377.6 12 - < 18 45 (29) 32.8 14.5-77.5 1.6-1855.2 Total 155 (100) 15.2 8.2-31.6 0.2-1855.2 a Hepcidin was below the detection limit of 0.5 nM in 26 out of 157 males (17%): 0-<2 years: 0 out of 11 (0%), 2-<6 years: 2 out of 29 (7%), 6-<12 years: 6 out of 71 (8%), 12-17 years: 18 out of 46 (39%) Hepcidin was below the detection limit in 19 out of 109 females (17%): (0-<2 years: 1 out of 6 (2%), 2-<6 years: 7 0 out of 18 (0%),, 6-<12 years: 6 out of 35 (17%), 12-17 years: 12 out of 50 (24%) Abbreviations: Min-Max denotes minimum-maximum