Albertine Donker

Standardized Pediatric Hepcidin Values 239 7 Univariable linear regression analysis ( Supplemental Table 4, Supplemental Table 5 ) showed that hepcidin/ferritin decreased and TSAT/hepcidin increased with aged in both sexes. Both effects were stronger in males compared to females. Biochemical correlates of hepcidin/ferritin and TSAT/hepcidin ratios Regression analyses for the hepcidin/ferritin and TSAT/hepcidin ratios adjusted for age and time of blood sampling are presented in Table 5 and Table 6 , respectively. R 2 for age as a continuous variable and sampling time as a categorical variable alone was 26.8 % and 13.6% and 21.3% and 6.5% for the log-transformed hepcidin/ferritin and TSAT/hepcidin ratio in males and females respectively. Sex-specific multivariable models were constructed for both ratios including age (as a categorical variable; age groups) and time of blood sampling and those variables that were significantly associated with these ratios after adjustment for age and time of blood sampling. The hepcidin/ferritin ratio was significantly correlated with CRP and underweight BMI in males and with CRP in females, after correction for age and time of blood sampling ( Table 5 ). The sex-specific model with the relevant correlates explained 32.9 % of the hepcidin/ferritin ratio variation in males and 14.3 % in females ( Supplemental Table 6 ). The TSAT/hepcidin ratio was statistically significantly correlated with multiple biochemical correlates in both males and females after adjustment for age and time of blood sampling ( Table 6 ). The sex-specific multivariable models including these parameters explained 46.0 % and 22.8 % of the TSAT/hepcidin ratio variation in males and females respectively ( Supplemental Table 7 ).