Albertine Donker

Chapter 7 256 Supplemental Table 1. Hemoglobin, iron status indicators, hepcidin and CRP for different age groups and sex Laboratory variables Males Age 0-<2 years n (%) median p25-p75 Min-Max Hemoglobin, g/dL 11(7) 11.0 10.7-11.7 10.1-12.5 Ferritin, µg/L 11 (7) 48.0 30.0-69.0 20.0-97.0 Iron, µmol/L 11 (7) 11.0 9.0-13.0 3.0-15.0 TIBC, µmol/L 11 (7) 63.0 61.0-67.0 56.0-72.0 TSAT, % 11 (7) 16.0 13.0-20.0 5.0-21.0 sTfR, mg/L 11 (7) 1.6 1.4-1.7 1.4-1.8 hepcidin, nmol/L 11 (7) 1.8 1.1-7.3 0.9-20.9 CRP, mg/L 11(7) 0.3 0.1-0.9 0.1-4.6 Age 2-<6 years n (%) median p25-p75 Hemoglobin, g/dL 29 (18) 11.7 11.3-12.3 10.4-14.1 Ferritin, µg/L 28 (18) 31.5 24.0-44.8 13.0-97.0 Iron, µmol/L 28 (18) 15.5 10.3-18.0 2.0-22.0 TIBC, µmol/L 28 (18) 66.0 59.2-71.8 50.0-83.0 TSAT, % 28 (18) 23.5 17.0-27.8 10.0-32.0 sTfR, mg/L 29 (18) 1.5 1.0-1.6 1.0-2.5 hepcidin, nmol/L 29 (18) 2.0 1.0-3.3 0.1-7.0 CRP, mg/L 28 (18) a 0.2 0.1-0.5 0.0-1.6 Age 6-<12 years n (%) median p2.5-p97.5 Hemoglobin, g/dL 71 (45) 12.3 10.8-14.0 10.6-14.2 Ferritin, µg/L 71 (45) 42.0 17.4-98.4 15.0-120.0 Iron, µmol/L 71 (45) 16.0 7.0-26.4 3.0-28.0 TIBC, µmol/l 71 (45) 63.0 44.6-82.0 35.0-90.0 TSAT, % 71 (45) 27.0 10.6-43.4 5.0-45.0 sTfR, mg/L 70 (44) 1.2 0.9-1.7 0.9-1.8 hepcidin, nmol/L 71 (45) 1.7 0.1-11.5 0.1-15.5 CRP, mg/L 71 (45) 0.2 0.0-3.5 0.0-3.7 Age 12-< 18 years n (%) median p2.5-p97.5 Hemoglobin, g/dL 46 (29) 14.2 12.1-16.0 12.0-16.0 Ferritin, µg/L 46 (29) 45.0 19.2-99.8 19.0-100.0 Iron, µmol/L 45 (28) 17.0 7.2-33.6 7.0-34.0 TIBC, µmol/L 46 (29) 67.0 53.2-85.5 53.0-86.0 TSAT, % 45 (28) 25.0 10.3-53.1 10.0-54.0 sTfR, mg/L 46 (29) 1.2 0.8-2.3 0.8-2.3 hepcidin, nmol/L 46 (29) 0.7 0.0-9.3 0.0-9.3 CRP, mg/L 46 (29) 0.3 0.0-4.7 0.0-4.9 Age 0-< 18 years 157 (100) a In a 3 year oldmale, CRPwas missing. Hepcidin was low (0.58 nM) in this child, arguing against inflammation. Therefore this case was not excluded although CRP>5 mg/L was an exclusion criterion for the study.