Albertine Donker

Chapter 7 262 Supplemental Table 3. Univariable linear regression for serum hepcidin concentrations (nmol/L) Males 95% CI p Variable Beta a Lower limit Upper limit Hb, g/dL -0.102 -0.170 -0.034 0.003 Reticulocytes, x10^9/L -0.001 -0.008 0.005 0.656 MCV, fL -0.028 -0.049 -0.007 0.009 Ferritin, µg/L b 1.118 0.704 1.531 0.000 Iron, µmol/L -0.006 -0.021 0.010 0.479 TIBC, µmol/l -0.009 -0.020 0.001 0.089 TSAT, % 0.00 -0.010 0.010 0.979 sTfR, µg/mL -0.000 -0.329 0.328 0.998 ALT, IU/L b 0.636 0.033 1.239 0.039 CRP, mg/L b 0.234 0.099 0.369 0.001 Age, years -0.038 -0.056 -0.021 0.000 Age group, years 0-< 2 ref ref ref 2-<6 -0.204 -0.559 0.152 0.259 6-<12 -0.187 -0.512 0.138 0.258 12-<18 -0.660 -0.997 -0.323 0.000 Age, years <12 12-< 18 -0.487 -0.663 -0.312 0.000 BMI c Normal weight ref ref ref Underweight 0.560 -0.073 1.192 0.082 Overweight 0.144 -0.129 0.416 0.299 Adipose 0.320 -0.174 0.813 0.202 Time blood sampling 8-12 PM ref ref ref 12-3 PM 0.196 0.009 0.382 0.040 3- 6 PM 0.341 0.087 0.595 0.009 a Beta expresses the change in the dependent variable -log-transformed serum hepcidin- that is associated with a 1-unit change in the independent variable. Independent variables marked with b were log-transformed as well; the interpretation of the regression coefficients for these variables is as follows: a 1% change in the independent variable corresponds to a beta % change in serum hepcidin. c BMI was assessed according to international standards established by Cole et al 11 Abbreviations: ref denotes reference category