Albertine Donker

Chapter 7 266 Supplemental Table 5. Univariable linear regression for TSAT/hepcidin ratio (%/nmol/L) Males 95% CI p Variable Beta a Lower limit Upper limit R 2 , % Hb, g/dL 0.142 0.071 0.214 8.6 0.000 Reticulocytes, x10^9/L -0.001 -0.008 0.006 0.0 0.815 MCV, fL 0.047 0.025 0.069 9.8 0.000 Ferritin, µg/L b -1.024 -1.475 -0.573 11.0 0.000 Iron, µmol/L 0.034 0.018 0.050 9.7 0.000 TIBC, µmol/L 0.005 -0.006 0.016 0.5 0.396 sTfR, µg/mL -0.324 -0.695 0.046 1.3 0.086 ALT, IU/L b -0.828 -1.468 -0.189 3.5 0.011 CRP, mg/L b -0.329 -0.470 -0.188 11.6 0.000 Age, years 0.050 0.031 0.069 14.9 0.000 Age group, years 0-< 2 ref ref ref 2-<6 0.377 0.002 0.752 18.0 0.049 6-<12 0.430 0.088 0.771 0.014 12-<18 0.896 0.542 1.250 0.000 Age, years <12 12-< 18 0.523 0.334 0.712 15.8 0.000 BMI c Normal weight ref ref ref Underweight -0.787 -1.454 -0.120 3.6 0.021 Overweight -0.222 -0.510 0.065 0.129 Adipose -0.350 -0.871 0.171 0.186 Time blood sampling 8-12 PM ref ref ref 12-3 PM -0.095 -0.298 0.107 1.6 0.355 3- 6 PM -0.292 -0.568 -0.017 0.038 a Beta expresses the change in the dependent variable- log transformed TSAT/hepcidin ratio- that is associated with a 1-unit change in the independent variable. Independent variables marked with b were log-transformed; the interpretation of the regression coefficients for these variables is as follows: a 1% change in the independent variable corresponds to a beta/100 unit change in the TSAT/hepcidin ratio. c BMI was assessed according to international standards established by Cole et al 11 Abbreviations: ref denotes reference category