Albertine Donker

Chapter 7 270 Supplemental Table 7. Results of multivariable linear regression analyses for TSAT/hepcidin (%/nmoL) ratio stratified by sex Males 95% CI Variable Beta a Lower limit Upper limit p Age, years 0-<2 ref ref ref 2-<6 0.221 -0.108 0.550 0.186 6-<12 0.411 0.106 0.716 0.009 12-<18 0.912 0.589 1.236 0.000 Time Blood sampling 7.30 AM-12 PM ref ref ref 12 -3 PM -0.137 -0.297 0.022 0.090 3- 6 PM -0.408 -0.626 -0.189 0.000 Ferritin, µg/L b -0.972 -1.388 -0.556 0.000 Iron, µmol/L 0.012 -0.003 0.027 0.104 sTfR, mg/L na na na na ALT, IU/L b 0.075 -0.484 0.635 0.790 CRP, mg/L b,c -0.170 -0.303 -0.038 0.012 BMI d Normal weight ref ref ref Underweight -0.636 -1.159 -0.112 0.018 Overweight -0.197 -0.423 0.029 0.087 Adipose -0.096 -0.522 0.331 0.659 a Beta expresses the change in the dependent variable – log transformed TSAT/hepcidin ratio- that is associated with a 1-unit change in the independent variable. Independent variables marked with b were log-transformed; the interpretation of the regression coefficients for these variables is as follows: a 1% change in the independent variable corresponds to a beta % change in the TSAT/hepcidin ratio c CRP levels of children were between > 0.1 and < 5 mg/L d BMI was assessed according to international standards established by Cole et al 11 Abbreviations: na denotes not applicable; ref, reference category