Sarah Bos

101 Efficacy of pro- and anticoagulant strategies in plasma 6 Figure 4. Absolute ETP levels from thrombomodulin modified thrombin generation testing in plasma of controls, and patients after partial hepatectomy prior to (-) and after (+) in vitro addition of anticoagulants. Start is after induction of anesthesia, POD = postoperative day. Shown aremedians with error bars indicating interquartile ranges, and the proportional difference in ETP upon addition of anticoagulants. Statistical differences indicated are differences in proportional change in ETP upon addition of anticoagulants between controls and patients. * p < 0.05 vs controls, ** P < 0.01 vs controls, *** P < 0.001 vs controls. LMWH = low molecular weight heparin, UFH = unfractionated heparin, Dabi = dabigatran, Riva = rivaroxaban. In vitro efficacy of pro- and antihemostatic agents in samples taken during and after PPPD We studied changes in routine hemostatic tests and total thrombin generation in samples taken during and after PPPD. The INR increased during and after surgery, and began to normalize at day 3. Plasma fibrinogenwas slightly elevated at the start of surgery, decreased during surgery, and was substantially elevated thereafter