Sarah Bos

114 CHAPTER 6 Supplementary table 1. Endogenous thrombin potential in absence or presence of in vitro addition of pro- and anticoagulant drugs in plasma of patients undergoing orthotopic liver transplantation OLT Sample Absolute ETP in absence of drug P values vs control Absolute ETP in presence of drug P values vs control % difference in ETP P values vs control FFP Control T1 T2 T3 T4 442 [349-720] 962 [834-1128] 1075 [895-1203] 792 [685-882] 1001 [893-1118] < 0.001 < 0.001 0.017 < 0.001 508 [414-765] 1016 [918-1140] 1198 [985-1326] 864 [670-973] 1105 [1007-1223] < 0.001 < 0.001 0.018 < 0.001 13 [1.3-21] 5.1 [-3.1-15] 7.6 [0.1-21] 7.2 [3.4-16] 11 [1.8-22] ns ns ns ns PCC Control T1 T2 T3 T4 442 [349-720] 962 [834-1128] 1075 [895-1203] 792 [685-882] 1001 [893-1118] < 0.001 < 0.001 0.017 < 0.001 915 [745-1374] 2111 [1693-2421] 2481 [2011-3040] 1962 [1712-2198] 2459 [2001-2651] < 0.001 < 0.001 < 0.001 < 0.001 94 [66-123] 114 [88-146] 118 [94-161] 164 [129-199] 147 [109-192] ns 0.02 < 0.001 0.003 rFVIIa Control T1 T2 T3 T4 442 [349-720] 962 [834-1128] 1075 [895-1203] 792 [685-882] 1001 [893-1118] < 0.001 < 0.001 0.017 < 0.001 585 [484-770] 906 [787-125] 1032 [861-1174] 685 [590-871] 1016 [857-1109] < 0.001 < 0.001 0.153 < 0.001 21 [8.6-43] -1.6 [-8.5-0.2] -3.4 [-8.1 - -0.1] -6.1 [-15.1- 3.6] -0.8 [-4.7-1.1] < 0.001 < 0.001 < 0.001 < 0.001 LMWH Control T1 POD1 POD3 POD6 442 [349-720] 962 [834-1128] 1170 [867-1281] 1011 [713-1195] 796 [680-1084] < 0.001 < 0.001 0.003 0.006 261 [191-378] 327 [215-464] 634 [455-715] 462 [304-705] 343 [254-535] 0.001 < 0.001 0.017 0.043 46 [33-59] 50 [44-57] 43 [35-53] 46 [36-56] 52 [46-56] ns ns ns ns UFH Control T1 POD1 POD3 POD6 442 [349-720] 962 [834-1128] 1170 [867-1281] 1011 [713-1195] 796 [680-1084] < 0.001 < 0.001 0.003 0.006 180 [128-304] 265 [122-401] 307 [144-417] 253 [172-502] 153 [56-379] ns ns ns ns 59 [40-76] 74 [60-84] 68 [58-85] 70 [55-76] 74 [51-87] ns ns ns ns Dabigatran Control T1 POD1 POD3 POD6 442 [349-720] 962 [834-1128] 1170 [867-1281] 1011 [713-1195] 796 [680-1084] < 0.001 < 0.001 0.003 0.006 372 [272-522] 148 [117-384] 256 [87-377] 358 [0-527] 0 [0-536] 0.002 0.002 ns 0.013 27 [15-38] 80 [68-87] 80 [69-92] 67 [53-100] 100 [54-100] < 0.001 < 0.001 < 0.001 < 0.001