Sarah Bos

115 Efficacy of pro- and anticoagulant strategies in plasma 6 OLT Sample Absolute ETP in absence of drug P values vs control Absolute ETP in presence of drug P values vs control % difference in ETP P values vs control Rivaroxaban Control T1 POD1 POD3 POD6 442 [349-720] 962 [834-1128] 1170 [867-1281] 1011 [713-1195] 796 [680-1084] < 0.001 < 0.001 0.003 0.006 160 [112-280] 703 [585-977] 848 [578-1053] 732 [442-948] 487 [407-765] < 0.001 < 0.001 < 0.001 < 0.001 64 [58-69] 25 [13-34] 22 [18-33] 27 [21-35] 34 [26-43] < 0.001 < 0.001 < 0.001 < 0.001 Shown aremedians (interquartile ranges). OLT, orthotopic liver transplantation; FFP, fresh frozen plama; PCC, prothrombin complex concentrate; rFVIIa, recombinant factor VIIa; LMWH, low-molecular weight heparin; UFH, unfractionated heparin; ETP, endogenous thrombin potential. T1 is after induction of anesthesia, T2 is 30 minutes after the start of the anhepatic phase, T3 is 30 minutes after reperfusion, T4 is at the end of surgery; POD, post-operative day.