Sarah Bos

116 CHAPTER 6 Supplementary table 2. Endogenous thrombin potential in absence or presence of in vitro addition of pro- and anticoagulant drugs in plasma of patients undergoing partial hepatectomy PHEP Sample Absolute ETP in absence of drug P values vs control Absolute ETP in presence of drug P values vs control % difference in ETP P values vs control FFP Control T1 T2 442 [349-720] 862 [597-1022] 1022 [945-1230] 0.001 < 0.001 508 [414-765] 702 [594-872] 976 [803-1204] 0.01 < 0.001 13 [1.3-21] -6.9 [-20- 2.0] -9.8 [-14 - -1.6] < 0.001 < 0.001 PCC Control T1 T2 442 [349-720] 862 [597-1022] 1022 [945-1230] 0.001 < 0.001 915 [745-1374] 1425 [1101-1725] 2100 [1902-2341] 0.001 < 0.001 94 [66-123] 79 [66-93] 89 [82-113] ns ns rFVIIa Control T1 T2 442 [349-720] 862 [597-1022] 1022 [945-1230] 0.001 < 0.001 585 [484-770] 803 [615-926] 1018 [[869-1168] 0.02 < 0.001 21 [8.6-43] -2.7 [-14-6.2] -4.1 [-7.9-4.2] < 0.001 < 0.001 LMWH Control T1 POD1 POD3 POD6 442 [349-720] 862 [597-1022] 1126 [949-1271] 1294 [1036-1449] 1166 [885-1342] 0.001 < 0.001 < 0.001 < 0.001 180 [128-304] 289 [234-419] 598 [472-756] 840 [647-1027] 659 [523-805] ns < 0.001 < 0.001 < 0.001 46 [33-59] 60 [52-71] 42 [38-49] 32 [22-41] 37 [31-50] 0.003 ns 0.03 ns UFH Control T1 POD1 POD3 POD6 442 [349-720] 862 [597-1022] 1126 [949-1271] 1294 [1036-1449 1166 [885-1342] 0.001 < 0.001 < 0.001 < 0.001 180 [128-304] 154 [93-244] 335 [204-530] 344 [190-808] 392 [137-785] ns 0.003 0.005 0.03 59 [40-76] 83 [70-89] 69 [51-82] 75 [46-85] 57 [47-80] 0.003 ns ns ns Dabigatran Control T1 POD1 POD3 POD6 442 [349-720] 862 [597-1022] 1126 [949-1271] 1294 [1036-1449 1166 [885-1342] 0.001 < 0.001 < 0.001 < 0.001 372 [272-522] 472 [428-547] 374 [225-508] 489 [330-594] 588 [39-680] ns ns ns ns 27 [15-38] 44 [24-54] 66 [52-79] 64 [52-73] 55 [37-67] ns < 0.001 0.001 0.01 Rivaroxaban Control T1 POD1 POD3 POD6 442 [349-720] 862 [597-1022] 1126 [949-1271] 1294 [1036-1449 1166 [885-1342] 0.001 < 0.001 < 0.001 < 0.001 160 [112-280] 401 [274-464] 850 [693-912] 968 [833-1189] 747 [603-1049] < 0.001 < 0.001 < 0.001 < 0.001 64 [58-69] 53 [44-60] 27 [20-38] 23 [12-36] 29 [19-41] 0.003 < 0.001 0.001 < 0.001 Shown are medians (interquartile ranges). PHEP, partial hepatectomy; FFP, fresh frozen plama; PCC, prothrombin complex concentrate; rFVIIa, recombinant factor VIIa; LMWH, low-molecular weight heparin; UFH, unfractionated heparin, ETP, endogenous thrombin potential. T1 is after induction of anesthesia, T2 is at the end of surgery; POD, post-operative day.