Sarah Bos

117 Efficacy of pro- and anticoagulant strategies in plasma 6 Supplementarytable3. Endogenous thrombinpotential ofpro- andanticoagulantdrugs inplasmaofpatientsundergoingpyloricpreservingpancreaticoduodenectomy PPPD Sample Absolute ETP in absence of drug P values vs control Absolute ETP in presence of drug P values vs control % difference in ETP P values vs control FFP Control T1 T2 442 [349-720] 810 [618-1132] 1081 [770-1283] 0.001 < 0.001 508 [414-765] 730 [566-1026] 949 [790-1153] 0.009 < 0.001 13 [1.3-21] -8.7 [-12- -3.6} -6.8 [-17- -0.4] < 0.001 < 0.001 PCC Control T1 T2 442 [349-720] 810 [618-1132] 1081 [770-1283] 0.001 < 0.001 915 [745-1374] 1396 [1103-2104] 2337 [1461-2782] 0.002 < 0.001 94 [66-123] 78 [65-95} 102 [81-132] ns ns rFVIIa Control T1 T2 442 [349-720] 810 [618-1132] 1081 [770-1283] 0.001 < 0.001 585 [484-770] 767 [699-1139] 1124 [893-1318] 0.005 < 0.001 21 [8.6-43] 0.3 [-8- 15] 2.1 [-1.3 -13} 0.01 0.003 LMWH Control T1 POD1 POD3 POD6 442 [349-720] 810 [618-1132] 1105 [1007-1350] 1323 [1132-1442] 948 [721 -1250] 0.001 < 0.001 < 0.001 0.001 180 [128-304] 316 [158-408] 663 [478-812] 883 [644-1083] 422 [256-818] ns < 0.001 < 0.001 0.017 46 [33-59] 65 [59-75] 43 [32-57] 31 [24-46] 52 [31-67] < 0.001 ns ns ns UFH Control T1 POD1 POD3 POD6 442 [349-720] 810 [618-1132] 1105 [1007-1350] 1323 [1132-1442] 948 [721 -1250] 0.001 < 0.001 < 0.001 0.001 180 [128-304] 121 [61-223] 225 [135-405] 354 [241-475] 225 [102-378] 0.018 ns 0.01 ns 59 [40-76] 87 [83-92] 82 [69-88] 74 [64-80] 79 [65-86] < 0.001 0.014 ns 0.05 Dabigatran Control T1 POD1 POD3 POD6 442 [349-720] 810 [618-1132] 1105 [1007-1350] 1323 [1132-1442] 948 [721 -1250] 0.001 < 0.001 < 0.001 0.001 372 [272-522] 504 [370-658] 369 [286-456] 525 [435-616] 527 [432-663] ns ns 0.024 0.03 27 [15-38] 46 [25-58] 67 [58-78] 60 [51-69] 47 [20-63] 0.05 < 0.001 < 0.001 ns Rivaroxaban Control T1 POD1 POD3 POD6 442 [349-720] 810 [618-1132] 1105 [1007-1350] 1323 [1132-1442] 948 [721 -1250] 0.001 < 0.001 < 0.001 0.001 160 [112-280] 341 [274-519] 775 [532-926] 973 [687-1073] 666 [355-884] < 0.001 < 0.001 < 0.001 < 0.001 64 [58-69] 54 [49-58] 35 [26-44] 28 [23-31] 42 [34-51] < 0.001 < 0.001 < 0.001 0.002 Shown are medians (interquartile ranges). PPPD, pyloric preserving pancreaticoduodenectomy; FFP, fresh frozen plama; PCC, prothrombin complex concentrate; rFVIIa, recombinant factor VIIa; LMWH, low-molecular weight heparin; UFH, unfractionated heparin; ETP, endogenous thrombin potential. T1 is after induction of anesthesia, T2 is at the end of surgery; POD, post-operative day.