Sarah Bos

Different parts of this thesis and PhD research were financially supported by the University of Groningen, Graduate School of Medical Science, Daiichi Sankyo, Ferring and Norgine. Cover design and Lay-out: Publiss | www.publiss.nl Print: Ridderprint | www.ridderprint.nl © Copyright 2021: Sarah Bos, The Netherlands All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, by photocopying, recording, or otherwise, without the prior written permission of the author.