Sarah Bos

26 CHAPTER 2 Figure 1. Plasma levels of proteins involved in primary hemostasis. Levels of VWF (A), ADAMTS13 (B) and sPselectin (C) were measured in patients with cirrhosis of varying etiologies and healthy controls. VWF, von Willebrand factor, ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13, sP-selectin, soluble P-selectin, PSC, primary sclerosing cholangitis, PBC, primary biliary cholangitis, NASH, non-alcoholic steatohepatitis, ALD, alcoholic liver disease, viral comprises hepatitis B and hepatitis C. Horizontal lines indicate median and IQR. *p < 0.05, *** p < 0.001 compared to controls. Thrombin generation, PT, APTT All the parameters of thrombomodulin-modified TGA were increased across all etiologies compared to controls as depicted in Table 2 and Figure 2. The ETP for the patients varied from 719 [527-859] for ALD to 670 [381-786] for PSC/PBC, compared to 420 [305-581] in controls. The ETP variation between etiologies remained present when only patients with CTP A were analyzed. The PT was significantly higher in all etiologies compared to controls, with the highest levels in ALD (Table 2). The APTT was significantly increased in patients with cholestatic disease, but normal in NASH and alcohol-related cirrhosis and slightly elevated in viral cirrhosis.