Sarah Bos

27 Hemostatic profiles are similar across all etiologies of cirrhosis. 2 PSC/PBC NASH ALD Viral Control TGA lagtime (min) 1.94 (1.3) a 1.71 (0.4) 1.67 (0.4) 1.91 (0.4) 1.53 (0.2) TGA ETP (nM IIa * min) 670 (381- 786) a 683 (528- 940) c 753 (609-944) c 719 (527-859) b 420 (305-581) TGA Peak (nM IIa) 160 (99-195) 176 126- 204) b 177 (160-196) c 156 (115-202) 116 (88-164) TGA Velocity (nM/ min) 88 (48-106) 94 (69-120) b 96 (82-113) c 79 50-107) 64 (46-96) PT (sec) 12.8 (1.4) c 13.1 (1.8) c 13.8 (2.3) c 13.3 (2.0) c 11.2 (0.7) APTT (sec) 37.5 (3.5) a 34.1 (3.4) 35.4 (4.3) 36.8 (3.9) 35.1 (2.9) Table 2. Global coagulation tests Abbreviations: ALD, alcoholic liver disease, viral comprises hepatitis B and hepatitis C; aPTT, activated partial thromboplastin time; ETP, endogenous thrombin potential; NASH, non-alcoholic steatohepatitis; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; PT, pro-thrombin time; TGA, thrombin generation assay. Note: Data are expressed as mean (standard deviation), or median (interquartile range). a p < 0.05 vs. control, b p < 0.01 vs. Control, c p < 0.001 vs. control. Figure 2. Thrombin generation assay (TGA) in the presence of thrombomodulin (TM+). Thrombomodulin-modified thrombin generation was measured in patients with cirrhosis of varying etiologies and healthy controls. ETP, endogenous thrombin potential, PSC, primary sclerosing cholangitis, PBC, primary biliary cholangitis, NASH, non-alcoholic steatohepatitis, ALD, alcoholic liver disease, viral comprises hepatitis B and hepatitis C. Horizontal lines indicate median and IQR. *p < 0.05, ** p < 0.01, *** p < 0.001 compared to controls.