Sarah Bos

29 Hemostatic profiles are similar across all etiologies of cirrhosis. 2 Figure 3. Fibrin parameters. The permeability coefficient (Ks, calculated following Darcy’s Law) (A) and fibrinogen level (B) was measured in plasma of patients with cirrhosis of varying etiologies and healthy controls. PSC, primary sclerosing cholangitis, PBC, primary biliary cholangitis, NASH, non-alcoholic steatohepatitis, ALD, alcoholic liver disease, viral comprises hepatitis B and hepatitis C. Horizontal lines indicate median and IQR. ** p < 0.01, *** p < 0.001 compared to controls. Fibrinolysis Clot lysis time was higher in patients with cholestatic disease, NASH and ALD compared to controls and only reached significance in the first two. In patients with cirrhosis due to viral disease the clot lysis time was similar compared to controls (fig 4). Plasma levels of PAI-1, an important determinant of clot lysis time, were significantly elevated in cholestatic disease and NASH, but not in alcohol- and viral-related cirrhosis. Plasma levels of tPA were significantly higher in all patient groups compared to controls (Table 4). Figure 4. Plasma fibrinolytic potential . Clot lysis times were measured in plasma of patients with cirrhosis of varying etiologies and healthy controls. PSC, primary sclerosing cholangitis, PBC, primary biliary cholangitis, NASH, non-alcoholic steatohepatitis, ALD, alcoholic liver disease, viral comprises hepatitis B and hepatitis C. Horizontal lines indicate median and IQR. *p < 0.05, ** p < 0.01 compared to controls.