Sarah Bos

41 Changes of in vitro potency of anticoagulant drugs 3 The following anticoagulants were tested • LMWH (Clexane, Sanofi-Aventis BV, Gouda, the Netherlands), 0.2 U/ml • Dabigatran (Alsachim, Illkirch Graffenstaden, France), 300 ng/ml • Apixaban (Alsachim, Illkirch Graffenstaden, France), 25 ng/ml Statistics Data are expressed as mean +/- standard deviation (SD) or as median with interquartile range (IQR) as appropriate. Frequencies and percentages are given for categorical variables. Groups were compared by One-way ANOVA (with the Bonferroni posttest) or Kruskal-Wallis H test (with Dunn's posttest) as appropriate. For statistical analyses, SPSS software was used (Statistical Package for the Social Sciences, version 23.0, Inc. Chicago, Illinois, USA). P values were considered to indicate a significant difference if p < 0.05. Results Patient characteristics The baseline characteristics of the study population are reported in table 1. Twenty-two patients with biopsy-proven NASH-related cirrhosis, fifteen patients with ASH-related cirrhosis, twenty lean subjects (BMI < 25kg/m2), and twenty overweight subjects (BMI > 25kg/m2) were included. Patients with cirrhosis had an increased prothrombin time (PT) and activated partial thromboplastin time (APTT) compared to controls. Mean model of end-stage liver disease (MELD) scores were slightly different between patients with NASH- and ASH-related cirrhosis. Table 1. Baseline characteristics of the study population Characteristics Lean controls Obese controls NASH cirrhosis ASH cirrhosis n=20 n=20 n= 22 n=15 Age (yrs) 45.0 (13.3) 40.0 (10.9) 61.4 (10.1) 53.9 (7.8) Gender (male) 6 (30) 4 (20) 9 (41) 12 (80) BMI 22.9 (1.1) 30.5 (4.1) 35.2 (5.4) 27.2 (5.7) PT 10.6 (9.4-12.1) 10.6 (9.1-11.4) 11.9 (10.2-17.2) 12.7 (9.8-16.9) APTT 28.9 (25.6-36.7) 30.1 (25.3-51.8) 32.6 (27.4-39.0) 34.5 (28.0-38.4) MELD 9.1 (3.0) 11.3 (3.4) Abbreviations: BMI: Body mass index, PT: Prothrombine time, APTT: Activated partial thromboplastine time, MELD: model for end-stage liver disease. Data are expressed as numbers (%) mean (SD) or median (range).