Sarah Bos

56 CHAPTER 4 Figure 1. Endogenous thrombin potential (ETP) at baseline and in samples taken at 3 time points during administration of 60 mg edoxaban once daily to 16 patients with cirrhosis and 16 healthy controls. The median percentual decrease is indicated and horizontal lines represent medians. # p < 0.05 vs controls At baseline, D-dimer levels were substantially higher in patients compared to controls. On day 3 and 7, D-dimer levels decreased significantly in controls compared to baseline (p < 0.05), but remained similar compared to baseline in patients (figure 2). Edoxaban plasma levels In patients and controls alike, anti Xa levels as a proxy for edoxaban plasma levels remained relatively constant during the week of administration, with median plasma levels around 200 ng/ml (figure 3). At day 3, two of the patients had particularly low edoxaban plasma levels, which may have been caused by lack of compliance. Adverse events Twopatientsexperiencedaminornosebleed.Onepatient decidednot toparticipate any further after this event. Mild bruising mainly at the site of venipuncture was present in 4 patients and 5 healthy controls. No further adverse events occurred.