Sarah Bos

69 Hemostatic complications in hepatobiliary surgery 5 hyperfibrinolysis impair hemostasis and might contribute to bleeding, whereas the VWF/ADAMTS13 imbalance and increased thrombin generation capacity support hemostasis and perhaps contribute to thrombosis. Postoperatively, hepatobiliary surgery is characterized by hypercoagulability, which includes VWF/ ADAMTS13 imbalance, enhanced thrombin generating capacity, and sustained hypofibrinolysis.(22,36,38) As all these factors have been shown to form a risk factor for thrombotic events in the general population, it is fair to hypothesize that the hypercoagulable status following hepatobiliary surgery may contribute to post-operative thrombotic events, but formal evidence for this is lacking.