Sarah Bos

96 CHAPTER 6 Table 2 . Clinical characteristics of the 20 orthotopic liver transplant patients Characteristics MELD 13 [9-17] CTP, n (%) A 3 (15) B 12 (60) C 5 (25) Etiology of cirrhosis, n (%) PBC 1 (5) PSC 6 (30) NASH 1 (5) ALD 5 (25) Auto-immune 1 (5) Other 6 (30) HBV 3 (15) HCV 1 (5) HCC 3 (15) Ascites 8 (40) Encephalopathy 4 (20) CIT, min 464 [403-522] WIT, min 36 [34-47] Donation after brain death (vs donation after cardiac death) 13 (65) MELD, model for end-stage liver disease, CTP, Child Turcotte Pugh, PBC, primary biliary cholangitis, PSC, primary sclerosing cholangitis, NASH, non-alcoholic steatohepatitis, ALD, alcoholic liver disease, HBV, hepatitis B virus, HCV, hepatitis C virus, HCC, hepatocellular carcinoma, CIT, cold ischemia time, WIT, warmth ischemia time. Numbers are represented as median [IQR] or numbers (%) When pooled normal plasma or rFVIIa was added to the plasma of controls or patients, there was very little change in total thrombin generation in patients and controls. In contrast, addition of PCC resulted in a substantial increase in the ETP in patients and controls. In patients, the increase in ETP was more pronounced with an exaggerated response particularly in samples after reperfusion and at the end of surgery. Addition of LMWH resulted in a comparable decrease in ETP between patients and controls, but absolute ETP values in the presence of LMWH remained significantly higher in patients compared to controls at all post-operative days. Addition of UFH led to a more pronounced, but non-significant, decrease in thrombin generation in patients compared to controls, but the absolute ETP values in the presence of heparin were similar or even higher in patients compared to controls (figure 2).