Sarah Bos

98 CHAPTER 6 all postoperative samples, but a more extensive anticoagulant effect was seen at baseline. Absolute thrombin generation in the presence of UFH was substantially higher in post-operative samples compared to controls. Dabigatran showed a larger relative decrease of ETP in patients compared to controls, but absolute values in the presence of dabigatran were comparable or even higher in patients. Rivaroxaban was much less effective in patients compared to controls, with ETP values in the presence of drug exceeding ETP values in controls in absence of drug. Figure 1. Absolute ETP levels from thrombomodulin modified thrombin generation testing in plasma of controls, and patients during OLT prior to (-) and after (+) in vitro addition of prohemostatic agents. Start is after induction of anesthesia, anhep is 30 minutes after the start of the anhepatic phase, reperf is 30 minutes after reperfusion, end is at the end of surgery. Shown are medians with error bars indicating interquartile ranges, and the proportional difference in ETP upon addition of procoagulants. Statistical differences indicated are differences in proportional change in ETP upon addition of procoagulants between controls and patients. * p < 0.05 vs controls, ** P < 0.01 vs controls, *** P < 0.001 vs controls. FFP = fresh frozen plasma, PCC = prothrombin complex concentrate, rFVIIa = recombinant factor VIIa.