Kim Annink

107 The long-term effect of perinatal asphyxia on hippocampal volumes age. More research is essential to determine at what age hippocampal atrophy first becomes visible. To answer this question, a follow-up study with sequential MRI scans of the brain of neonates with HIE is necessary, using a higher field strength of 3.0 Tesla instead of 1.5 Tesla. Additionally, an even larger follow-up study is necessary to investigate the memory problems in mild HIE and the exact association between hippocampal volumes and all fields of episodic memory. Further, research on the relation between episodic memory and the subregions of the hippocampus would provide us with an even more specific understanding of the long-term effect of HIE on hippocampal volumes and memory and the functional neuroanatomy of the hippocampus. CONCLUSIONS In conclusion, children with HIE have decreased hippocampal volumes, as well as impaired long-term episodic memory at the age of 9 to 10 years. Furthermore, hippocampal volumes are associated with long-term visuospatial memory impairment. FUNDING This work was supported by the Princess Beatrix Fund [MAR03-0122]. The PhD position of the first author Kim V. Annink is funded by the Horizon 2020 research and innovation Program of the European Union (call H2020-PHC-2015-two-stage, grant 667224, ALBINO). DISCLOSURES The authors have no conflict of interests to disclose 5