Kim Annink

117 The papez circuit and school-age outcome in HIE it was uncertain if this could be a partial volume effect. Abnormal was defined as an increased signal intensity of the mammillary bodies on the T2-weighted image, a low signal on T1-weighted imaging or diffusion restriction on DWI, in combination with swelling of the MB (10). Neurocognitive tests at 10 years of age All children completed a full neuropsychological assessment performed by a pediatric neuropsychologist. Intelligence was tested with the Wechsler Intelligence Scale for Children, Third edition (WISC-III-NL) (13). Total IQ (TIQ), Verbal IQ (VIQ) and Performance IQ (PIQ) were derived from the WISC-III-NL. The Processing Speed Index of the WISC-III-NL was used to evaluate the speed of information processing (13). The verbal long-term memory was tested with the 15-words test (14), which consists of five learning trials with immediate recall of words (resulting in a total score) and a delayed recall after 25 minutes (resulting in a delayed score). Verbal Working Memory was measured with the Digit Span task of the WISC-III-NL (13). Visual-spatial Working Memory was tested with the spatial span task of the Wechsler nonverbal scale of ability (15). Visual-spatial long-term memory was assessed with the Rey Complex Figure Test (16). To test attention, four subtests of the Test of Everyday Attention of Children were administered (17). The child’s behavior was evaluated by parents and the teacher using questionnaires. Parents completed the Child Behavior Checklist (CBCL for children aged 6-18 years) and the Behavior Rating Inventory of Executive Function (BRIEF), which is a questionnaire regarding well-organized, purposeful, goal-directed, and problem- solving behavior (18). Teachers completed the BRIEF and the Teacher’s Report Form for children aged 6-18 years that is comparable with the CBCL (19,20). Motor assessment at 10 years of age Motor performance was assessed with the Bruininks-Oseretsky Test of Motor Proficiency second edition (BOT-2). The BOT-2 scores four different domains: fine motor manual control, manual coordination, body coordination and strength and agility (21). Both a total composite score as composite scores of the four domains were used. Based on standard scores children are scored as well above average, above average, average, below average and well below average. 6