Kim Annink

123 The papez circuit and school-age outcome in HIE Table 1 shows the neonatal and childhood characteristics. Table 1: Neonatal and childhood characteristics. Characteristic non-HT (n=28) HT (n=22) p-value Male, n (%) 17 (60.7) 15 (68.2) 0.59 Gestational age in weeks, median (IQR) 40.86 (39.50-41.61) 40.21 (39.68-41.50) 0.53 Birth weight in gram, median (IQR) 3485 (3103 - 3700) 3710 (3280 – 4410) 0.009 * Apgar 1 min, median (IQR) 2 (2 – 4) 1 (1 – 2) 0.006* Apgar 5 min, median (IQR) 4 (3 – 6) 3.5 (3 – 4.75) 0.18 Apgar 10 min, median (IQR) 6 (4.5 – 7.5) 5 (4 – 6) 0.18 Highest lactate within first 12 hours after birth, median (IQR) 7.7 (3.65 – 11.13) 12.4 (5.73 – 19.13) <0.05* Lowest pH within first 12 hours after birth, median (IQR) 7.14 (6.99 – 7.34) 6.99 (6.78 – 7.23) 0.06 Seizures, n (%) No Yes, subclinical Yes, clinical 5 (17.9) 5 (17.9) 18 (64.3) 5 (22.7) 5 (22.7) 12 (54.5) 0.78 Worst aEEG background pattern, n (%) Normal (continuous normal voltage (+ sleep wake cycling), discontinuous low voltage) Abnormal (burst suppression, continuous low voltage, flat trace) 9 (75) 3 (25) 6 (38) 10 (63) 0.05 Neonatal MRI, n (%) No Yes 7 (25) 21 (75) 0 (0) 22 (100) 0.01* Total neonatal MRI score (total cohort), median (IQR) 8 (4.5 – 17.5) 4 (0 – 11) 0.03* Total neonatal MRI score (Utrecht), median (IQR) 8.5 (6.5-19.0) 2.0 (0.0-12.5) 0.01* Education mother**, median (IQR) 6 (5-6) 6 (5-6) 0.82 Education father**, median (IQR) 5 (5-6) 5 (5-6) 0.69 Age at follow-up study in months, median (IQR) 126 (125 – 127) 125 (123.8 – 127) 0.12 6