Kim Annink

124 Chapter 6 Table 1: Continued Characteristic non-HT (n=28) HT (n=22) p-value Weight in kg, median (IQR) 34.8 (31.0 – 40.8) 38.4 (34.3 – 44.9) 0.14 Length in cm, median (IQR) 145.0 (141.3 – 148.0) 146.0 (142.1 – 149.5) 0.16 Head circumference in cm, median (IQR) 53.5 (51.5 – 54.2) 54.1 (53.0 – 54.5) 0.07 Grade repetition or skipping, n (%) No Grade repetition Grade skipping 21 (75) 7 (25) 0 (0) 18 (81.8) 3 (13.6) 1 (4.5) 0.42 Epilepsy, n (%) Never In the past At present, without medication At present, with medication 23 (82.1) 3 (10.7) 0 (0) 2 (7.1) 19 (86.4) 2 (9.1) 1 (4.5) 0 (0) 0.41 Audiovisual problems, n (%) No Visual problems Hearing problems 17 (60.7) 9 (32.1) 2 (7.1) 17 (77.3) 4 (18.2) 1 (4.5) 0.46 * p-value < 0.05 ** SES according to Verhage classification The total neonatal MRI score of Weeke et al. was significantly higher in the non-HT group compared to the HT group, but significantly fewer neonatal MR scans were performed in this group. MRI was only performed in Isala Clinics in the pre- hypothermia era if brain injury was suspected. In the UMC Utrecht all patients underwent an MRI, analysis of this subgroup showed also higher neonatal MRI scores in the non-HT group. The MRI score of van Kooij et al. at 10 years of age was comparable between the HT (median 2 (range 1-5)) and non-HT group (median 2, (range 1-4), p=0.20). At 10 years of age, atrophy of the MB was present in 17% in the non-HT group and 50% in the HT group . Neurodevelopmental outcome Table 2 shows the motor and neuropsychological outcomes of the children in the non-HT and HT group. There were no differences in behavioral problems between the non-HT and HT group reported in CBCL and BRIEF questionnaires by parents or teachers.