Kim Annink

126 Chapter 6 In the total group, 36.7% of the children scored below average. In the non-HT group, two infants had CP and could not be tested on the BOT-2; they were considered to have an abnormal score. Two of the children in the HT group, had impaired function of one arm because of obstetric brachial plexus injury. In the total cohort, TIQ was below -2SD in 6.3% of the children and below -1SD in 29.2% of the children. VIQ was below -2SD in 2.1% and below -1SD in 21.3% of the children. PIQ was below -2SD in 8.7% and below -1SD in 37.0% of the children. The processing speed was below -2SD in 2.1% and below -1SD in 22.9% of the children. MRI – MB atrophy In the whole study group, 44 patients had a scan at 10 years of age that was considered to be of sufficient quality to score the MB and 39 patients had a neonatal MRI scan as well as an MRI scan at 10 years of age. Of the 44 patients, 38% had atrophy of the MB at 10 years of age. The majority (91%) of the infants with normal neonatal MB also had normal MB at 10 years, while 76% of the infants with abnormal neonatal MB had atrophy at 10 years of age. The majority (90%) of the infants with equivocal MB on their neonatal scan, had normal MB at 10 years (Table 3). Table 3: mammillary bodies on the neonatal MRI compared to the MRI at 10 years of age. Neonatal MB score Normal MB at 10y Atrophy MB at 10y Normal, n (%) 10 (91) 1 (9) Equivocal, n (%) 9 (90) 1 (10) Abnormal, n (%) 4 (24) 13 (76) The third reader on MB scored the same as the others in 83% of the cases. In the three cases where the score was different, the MB was still present but smaller than usual. Birth weight, Apgar scores and pH did not differ between children with normal MB and atrophy of the MB at 10 years of age. Children with abnormal MB did have higher lactate levels compared to children with normal MB (13.6 vs 8.9 mmol/L, p=0.04). A trend towards increased neonatal MRI scores according to Weeke et al. was seen in the children with MB atrophy, but this did not reach significance.