Kim Annink

128 Chapter 6 Table 4: Neurodevelopmental outcome and MB at follow-up Test Normal MB at 10y (n=30) Atrophy MB at 10y (n=14) p-value Intelligence TIQ, mean (SD) 99.9 (13.5) 80.6 (11.3) <0.001* VIQ, mean (SD) 101.8 (13.3) 87.6 (8.9) 0.002* PIQ, mean (SD) 98.0 (14.2) 76.6 (10.5) <0.001* Processing Speed, mean (SD) 100.9 (16.7) 86.7 (10.5) 0.007 Memory Verbal long-term memory – immediate recall, mean decile score (SD) 4.4 (2.8) 1.1 (0.3) <0.001* Verbal long-term memory – delayed recall, mean decile score corrected for age (SD) 3.6 (2.7) 1.0 (0.0) <0.001* Verbal Working Memory, mean norm score (SD) 9.3 (3.3) 9.1 (4.1) 0.90 Visual-spatial Working Memory, mean t-score (SD) 48.2 (12.0) 47.0 (12.2) 0.76 Visual-spatial long-term memory direct recall, mean t-score (SD) 40.8 (14.3) 22.7 (4.9) <0.001* Visual-spatial long-term memory delayed recall, mean t-score (SD) 39.9 (11.5) 20.5 (2.4) <0.001* Attention Sustained attention, mean (SD) 8.3 (3.1) 8.2 (3.7) 0.95 Selective attention, mean (SD) 10.0 (2.1) 8.5 (3.0) 0.11 Motor outcome Total composite score, mean (SD) 47.9 (10.0) 38.9 (7.1) 0.004* Fine Manual Control standard score, mean (SD) 46.5 (9.1) 35.6 (5.9) <0.001* Manual Coordination standard score, mean (SD) 49.2 (9.0) 41.2 (10.0) 0.01 Body Coordination standard score, mean (SD) 42.6 (8.1) 36.9 (7.1) 0.03 Strength and agility standard score, mean (SD) 56.6 (9.5) 51.3 (8.7) 0.08 * For the outcomes of the neuropsychological assessments, after correction for multiple comparison, p-values < 0.004 were statistically significant. For the motor outcome, p-values < 0.01 were statistically significant. ** statistically significant