Kim Annink

135 The papez circuit and school-age outcome in HIE term follow-up into childhood, and maybe even adulthood, to assess definitive outcomes of infants with HIE. CONCLUSIONS In summary, children with HIE that were cooled still suffer from neurocognitive and memory problems at 10 years of age. Structures from the Papez circuit were strongly associated with neurocognitive and memory development. Neonatal abnormalities of the MB in the acute phase of HIE can be a biomarker to predict atrophy of the MB, which appears to be associated with neurodevelopmental difficulties at school-age. ACKNOWLEDGMENTS The authors thank all MRI technicians for their excellent help with conducting the MR scans. Furthermore, they thank Emma Dirkson, medical student, who helped with the DTI analysis and updating the database. FUNDING The study was funded by Vaillant Foundation and Neonatal Neurology Foundation. The PhD position of the first author Kim V. Annink is funded by the Horizon 2020 research and innovation Program of the European Union (call H2020-PHC-2015-two- stage, grant 667224, ALBINO). DISCLOSURES Floris Groenendaal is an expert witness in cases of perinatal asphyxia. He is also co- inventor of 2-iminobiotin for neonatal neuroprotection. The other authors have no conflict of interest to declare. 6