Kim Annink

167 Allopurinol: old drug, new indication in neonates? 14 . Coghlan JG, Flitter WD, Clutton SM, Panda R, Daly R, Wright G, et al. Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1994;107:248-56. 15 . Johnson WD, Kayser KL, Brenowitz JB, Saedi SF. A randomized controlled trial of allopurinol in coronary bypass surgery. Am Heart J. 1991;121:20-4. 16 . Kelkar A, Kuo A, Frishman WH. Allopurinol as a cardiovascular drug. Cardiol Rev. 2011;19:265-71. 17 . Okafor ON, Farrington K, Gorog DA. Allopurinol as a therapeutic option in cardiovascular disease. Pharmacol Ther. 2017;172:139-50. 18 . Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010;86:329-38. 19 . Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349-58. 20 . Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014;371:140-9. 21 . Inder TE, Volpe JJ. Mechanisms of perinatal brain injury. Semin Neonatol. 2000;5:3- 16. 22 . van Bel F, Groenendaal F. Drugs for neuroprotection after birth asphyxia: Pharmacologic adjuncts to hypothermia. Semin Perinatol. 2016;40:152-9. 23 . Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351:1985-95. 24 . Hilton GD, Nunez JL, Bambrick L, Thompson SM, McCarthy MM. Glutamate- mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR- induced release of Ca++ from intracellular stores and is prevented by estradiol. Eur J Neurosci. 2006;24:3008-16. 25 . Orrenius S, Burkitt MJ, Kass GE, Dypbukt JM, Nicotera P. Calcium ions and oxidative cell injury. Ann Neurol. 1992;32 S33-42. 26 . Dorrepaal CA, Berger HM, Benders MJ, van Zoeren-Grobben D, Van de Bor M, Van Bel F. Nonprotein-bound iron in postasphyxial reperfusion injury of the newborn. Pediatrics. 1996;98:883-9. 27 . Fellman V RK. Reperfusion Injury as the Mechanism of Brain Damage after Perinatal Asphyxia. Pediatric Research. 1997;41:599–606. 7