Kim Annink

209 Pharmacokinetics of allopurinol in the ALBINO trial REFERENCES 1 . Lee ACC, Kozuki N, Blencowe H, Vos T, Bahalim A, Darmstadt GL, et al. Intrapartum- related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Pediatr Res. 2013;74:50–72. 2 . Azzopardi D V, Strohm B, David Edwards A, Dyet L, Halliday HL, Juszczak E, et al. Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy. N Engl J Med. 2009;361:1349–58. 3 . Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;doi: 10.1002/14651858.CD003311.pub3. 4 . Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, et al. Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes. N Engl J Med. 2014;371(2):140–9. 5 . Van Bel F, Groenendaal F. Drugs for neuroprotection after birth asphyxia: Pharmacologic adjuncts to hypothermia. Semin Perinatol. 2016;40:152–9. 6 . Ferriero DM. Neonatal Brain Injury. N Engl J Med. 2004;351(19):1985–95. 7 . Stamp LK, Day RO, Yun J. Allopurinol hypersensitivity: investigating the cause and minimizing the risk. Nat Publ Gr. 2016;12:235–42. 8 . Shadid M, Buonocore G, Groenendaal F, Moison R, Ferrali M, Berger HM, et al. Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxia-ischemia. Neurosci Lett. 1998;248:5–8. 9 . Moorhouse PC, Grootveld M, Halliwell B, Quinlan JG, Guttetidge JMC. Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS letter 1987;213(1):23–8. 10 . Peeters-Scholte C, Braun K, Koster J, Kops N, Blomgren K, Buonocore G, et al. Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia. Pediatr Res. 2003;54:516–22. 11 . Torrance HL, Benders MJ, Derks JB, Rademaker CM, Bos AF, Van Den Berg P, et al. Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. Pediatrics. 2009;124:350–7. 12 . Palmer C, Towfighi J, Roberts RL, Heitjan DF. Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr Res. 1993;33(4):405–11. 13 . Williams GD, Palmer C, Heitjan DF, Smith MB. Allopurinol preserves cerebral energy metabolism during perinatal hypoxia-ischemia: A 31P NMR study in unanesthetized immature rats. Neurosci Lett. 1992;144:103–6. 9