Kim Annink

210 Chapter 9 14 . Marro P, Hoffman D, Schneiderman R, Mishra OP, Delivoria-Papadopoulos M. Effect of allopurinol on NMDA receptor modification following recurrent asphyxia in newborn piglets. Brain Res. 1998;787:71–7. 15 . Marro P, Baumgart S, Delivoria-Papadopoulos M, Zirin S, Corcoran L, McGaurn S, et al. Purine metabolism and inhibition of xanthine oxidase in severely hypoxic neonates going onto extracorporeal membrane oxygenation. Pediatr Res. 1997;41:513–20. 16 . Marro P, Mishra OP, Delivoria-Papadopoulos M. Effect of allopurinol on brain adenosine levels during hypoxia in newborn piglets. Brain Res. 2006;1073– 1074:444–50. 17 . Marro P, Mcgowan JE, Razdan B, Mishra OP, Delivoria-Papadopoulos M. Effect of allopurinol on uric acid levels and brain cell membrane Na+,K+-ATPase activity during hypoxia in newborn piglets. Brain Res. 1994;650:9–15. 18 . Van Bel F, Shadid M, Moison RMW, Dorrepaal CA, Fontijn J, Monteiro L, et al. Effect of Allopurinol on Postasphyxial Free Radical Formation, Cerebral Hemodynamics, and Electrical Brain Activity. Pediatrics. 1998;101(2):185–93. 19 . Benders MJNL, Bos AF, A Rademaker CM, Rijken M, Torrance HL, Groenendaal F, et al. Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006;91:163–5. 20 . Klumper J, Kaandorp JJ, Schuit E, Groenendaal F, Koopman-Esseboom C, Mulder EJH, et al. Behavioral and neurodevelopmental outcome of children after maternal allopurinol administration during suspected fetal hypoxia: 5-year follow up of the ALLO-trial. PLoS One. 2018;13(8):1–12. 21 . Kaandorp JJ, Benders MJNL, Schuit E, A Rademaker CM, Oudijk MA, Porath MM, et al. Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial. Arch Dis Child Fetal Neonatal Ed. 2015;100:F216–23. 22 . Kaandorp JJ, Van Bel F, Veen S, Derks JB, Groenendaal F, Rijken M, et al. Long- term neuroprotective effects of allopurinol after moderate perinatal asphyxia: Follow-up of two randomised controlled trials. Arch Dis Child Fetal Neonatal Ed. 2012;97(3):F162–6. 23 . Gunes T, Ozturk MA, Koklu E, Kose K, Gunes I. Effect of Allopurinol Supplementation on Nitric Oxide Levels in Asphyxiated Newborns. Pediatr Neurol. 2007;36:17–24. 24 . Annink KV, Franz AR, Derks JB, Rüdiger M, Van Bel F, Benders MJNL. Allopurinol: Old drug, new indication in neonates? Curr Pharm Des. 2017;23(38):5935–42. 25 . Chaudhari T, McGuire W. Allopurinol for preventing mortality and morbidity in newborn infants with hypoxic-ischaemic encephalopathy. Cochrane Database of Systematic Reviews 2012;7: CD006817. DOI: 10.1002/14651858.CD006817.pub3