Kim Annink

211 Pharmacokinetics of allopurinol in the ALBINO trial 26 . Maiwald CA, Annink KV, Rüdiger M, Benders MJNL, Van Bel F, Allegaert K, et al. Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic- ischemic brain injury on neurocognitive outcome (ALBINO): Study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III). BMC Pediatr. 2019;19(1):1–10. 27 . Van Kesteren C, Benders MJNL, Groenendaal F, Van Bel F, Ververs FFT, Rademaker CMA. Population Pharmacokinetics of Allopurinol in Full-Term Neonates With Perinatal Asphyxia. Ther Drug Monit. 2006;28:339–44. 28 . Van Den Broek MPH, Groenendaal F, Egberts ACG, Rademaker CMA. Effects of hypothermia on pharmacokinetics and pharmacodynamics: A systematic review of preclinical and clinical studies. Clin Pharmacokinet. 2010;49(5):277–94. 29 . Groenendaal F, Casaer A, Dijkman KP, Gavilanes AWD, De Haan TR, Ter Horst HJ, et al. Introduction of hypothermia for neonates with perinatal asphyxia in the Netherlands and flanders and the dutch-flemish working group on neonatal neurology. Neonatology. 2013;104(1):15–21. 30 . Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, et al. The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial. BMC Pediatr. 2008;8:1–12. 31 . Keizer RJ, van Benten M, Beijnen JH, Schellens JHM, Huitema ADR. Piraña and PCluster: A modeling environment and cluster infrastructure for NONMEM. Comput Methods Programs Biomed. 2011;101(1):72–9. 32 . West G, Brown J, Enquist B. A general model for the origin of allometric scaling laws in biology. Science. 1998;276(5309):122–6. 33 . Bergstrand M, Karlsson MO. Handling data below the limit of quantification in mixed effect models. AAPS J. 2009;11(2):371–80. 34 . Dosne AG, Bergstrand M, Karlsson MO. An automated sampling importance resampling procedure for estimating parameter uncertainty. J Pharmacokinet Pharmacodyn. 2017;44(6):509–20. 35 . Shah P, Riphagen S, Beyene J, Perlman M. Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2004;89(2):152–5. 36 . Zanelli S, Buck M, Fairchild K. Physiologic and pharmacologic considerations for hypothermia therapy in neonates. J Perinatol. 2011;31(6):377–86. 37 . Zhou J, Poloyac SM. The effect of therapeutic hypothermia on drug metabolism and response: Cellular mechanisms to organ function. Expert Opin Drug Metab Toxicol. 2011;7(7):803–16. 9