Kim Annink

272 Chapter 12 41 . Moorhouse PC, Grootveld M, Halliwell B, Quinlan JG, Guttetidge JMC. Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS letter 1987;213(1):23–8. 42 . Shadid M, Buonocore G, Groenendaal F, Moison R, Ferrali M, Berger HM, et al. Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxia-ischemia. Neurosci Lett. 1998;248:5-8. 43 . Benders MJNL, Bos AF, Rademaker CM, Rijken M, Torrance HL, Groenendaal F, et al. Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006;91:163–5. 44 . Klumper J, Kaandorp JJ, Schuit E, Groenendaal F, Koopman-Esseboom C, Mulder EJH, et al. Behavioral and neurodevelopmental outcome of children after maternal allopurinol administration during suspected fetal hypoxia: 5-year follow up of the ALLO-trial. PLoS One. 2018;13(8):1–12. 45 . Bel F van, Shadid M, Moison RMW, Dorrepaal CA, Fontijn J, Monteiro L, et al. Effect of Allopurinol on Postasphyxial Free Radical Formation, Cerebral Hemodynamics, and Electrical Brain Activity. Pediatrics. 1998;101(2):185-193. 46 . Torrance HL, Benders MJ, Derks JB, Rademaker CM, Bos AF, Van Den Berg P, et al. Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. Pediatrics. 2009;12:350-357. 47 . Kaandorp JJ, Van Bel F, Veen S, Derks JB, Groenendaal F, Rijken M, et al. Long- term neuroprotective effects of allopurinol after moderate perinatal asphyxia: Follow-up of two randomised controlled trials. Arch Dis Child Fetal Neonatal Ed. 2012;97(3):F162–6. 48 . Kaandorp JJ, Benders MJ, Schuit E, A Rademaker CM, Oudijk MA, Porath MM, et al. Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial. Arch Dis Child Fetal Neonatal Ed. 2015;100:F216–23. 49 . Gunes T, Ozturk MA, Koklu E, Kose K, Gunes I. Effect of Allopurinol Supplementation on Nitric Oxide Levels in Asphyxiated Newborns. Pediatr Neurol. 2007;36:17–24. 50 . Van Kesteren C, Benders MJNL, Groenendaal F, Van Bel F, Ververs FFT, Rademaker CMA. Population Pharmacokinetics of Allopurinol in Full-Term Neonates With Perinatal Asphyxia. Ther Drug Monit. 2006;28:339–44. 51 . Kaandorp JJ, Benders MJ, Schuit E, A Rademaker CM, Oudijk MA, Porath MM, et al. Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial. Arch Dis Child Fetal Neonatal Ed. 2015;100:F216–23.