Kim Annink

288 Chapter 13 26 . Benders MJNL, Bos AF, A Rademaker CM, Rijken M, Torrance HL, Groenendaal F, et al. Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006;91:163–5. 27 . Klumper J, Kaandorp JJ, Schuit E, Groenendaal F, Koopman-Esseboom C, Mulder EJH, et al. Behavioral and neurodevelopmental outcome of children after maternal allopurinol administration during suspected fetal hypoxia: 5-year follow up of the ALLO-trial. PLoS One. 2018;13(8):1–12. 28 . Bel F van, Shadid M, Moison RMW, Dorrepaal CA, Fontijn J, Monteiro L, et al. Effect of Allopurinol on Postasphyxial Free Radical Formation, Cerebral Hemodynamics, and Electrical Brain Activity. Pediatrics. 1998;101(2):185–93. 29 . Torrance HL, Benders MJ, Derks JB, Rademaker CM a, Bos AF, Van Den Berg P, et al. Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. Pediatrics. 2009;124:350–7. 30 . Kaandorp JJ, Van Bel F, Veen S, Derks JB, Groenendaal F, Rijken M, et al. Long- term neuroprotective effects of allopurinol after moderate perinatal asphyxia: Follow-up of two randomised controlled trials. Arch Dis Child Fetal Neonatal Ed. 2012;97(3):F162–6. 31 . Kaandorp JJ, N L Benders MJ, Schuit E, A Rademaker CM, Oudijk MA, Porath MM, et al. Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial. Arch Dis Child Fetal Neonatal Ed. 2015;100:F216–23. 32 . Gunes T, Ozturk MA, Koklu E, Kose K, Gunes I. Effect of Allopurinol Supplementation on Nitric Oxide Levels in Asphyxiated Newborns. Pediatr Neurol. 2007;36:17–24. 33 . Van Kesteren C, Benders MJNL, Groenendaal F, Van Bel F, Ververs FFT, Rademaker CMA. Population Pharmacokinetics of Allopurinol in Full-Term Neonates With Perinatal Asphyxia. Ther Drug Monit. 2006;28:339–44. 34 . Kaandorp JJ, Van Den Broek MPH, Benders NL, Oudijk MA, Porath MM, Oetomo SB, et al. Rapid target allopurinol concentrations in the hypoxic fetus after maternal administration during labour. Arch Dis Child Fetal Neonatal Ed. 2014;99:F144-148. 35 . Mcgaurn S, Davis LE, Krawczeniuk MM, Murphy JD, Jacobs ML, Norwood WI, et al. The Pharmacokinetics of Injectable Allopurinol in Newborns With the Hypoplastic Left Heart Syndrome. Pediatrics. 1994;94(6):820–3. 36 . Haan TR De, Bijleveld YA, Lee JH Van Der, Groenendaal F, Broek MPH Van Den, Dijk PH, et al. Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study. BMC Pediatr. 2012;12:45–52.