Kim Annink

35 The pattern of Purkinje cell injury in neonates with HIE 63x magnification (Figure 1). For each patient the pattern of PC injury was examined at two levels: (1) within the lobules (locations examined: the bases of the sulci and crown of lobules II, III, VIII, IX), and (2) within two folia (locations examined: the bases of the sulci and crown of a proximal folia and a distal folia of lobules II, III, V, VI, VIII, IX). The crown is defined as the most convex part of a folia or lobe and the base as the most concave part (Figure 1). The base of a sulcus is the mean value of both sides of the base. The anterior values are the average values of lobules II, III and V and the posterior values are the average of lobules VI, VIII and IX. However, data were only included throughout examination when all values within one lobule were available. Whenever lobular data were available, but data from the folia were missing (or vice versa), only lobular data were included since this was separately investigated. Figure 1: Locations photographed for analyses in the vermis. A. The red dots represent the proximal located folia in the anterior and posterior lobes. The blue dots represent the distal located folia in the anterior and posterior lobes. The orange (concave) curvatures represent the bases of the sulci of the anterior and posterior lobules, the green (convex) curvatures represent the crowns of the anterior and posterior lobules. B. Magnified folia. The yellow bow represents the crown, the pink curvatures represent the bases of the sulci of the folia. PC classification system PCs were counted and categorized at the above mentioned locations in the vermis using a newly developed PC classification system based on Hausmann et al. (19) by 2