Kim Annink

37 The pattern of Purkinje cell injury in neonates with HIE Figure 2: Examples of PC classification system. A. Crown of a proximal located folia of lobe 2. B. Normal PC. C. Abnormal PC. D. Non-classified PC because no nucleus or nucleolus is visible. Statistical analyses Statistical analyses were performed using IBM SPSS Statistics for Windows, version 25 (IBM New York 2013). Differences in PCs in the anterior and posterior lobe were calculated using the paired samples t-test for normally distributed data and a Wilcoxon-signed rank test for data that were not normally distributed. Differences in the number and percentage of PCs at the crown compared to the bases of the sulci within the lobules and within the proximal and distal folia were assessed using a paired samples t-test for normally distributed data and a Wilcoxon-signed rank test for data that were not normally distributed. P-values < 0.05 were considered significant. All data were corrected for multiple comparison analyses by multiplying the p-value with the number of comparisons per statistical test. 2